Unchained Labs

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Solutions

  • Biologics
  • Gene Therapy
  • Cell Therapy
  • LNPs
  • Genomics
  • Automation

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Aunty - The Queen of high-throughput protein stability characterisation

Aunty is the fastest and highest throughput protein stability characterisation  tool on the planet. Period.

With unrivalled fluorescence, static light scattering and  dynamic light scattering skills, Aunty blasts through thermal melting and aggregation  experiments — reading an entire 96-well plate of samples every minute of a thermal  ramp. Sift through piles of candidates, conditions, or formulations, with as many  replicates as you want. Aunty cranks out plates of results with unprecedented data  resolution, so you can find your winners at breakneck speed.

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Leprechaun - Lentivirus titre and structure 

The unmatched lentivirus and exosome characterisation tool.

Lentivirus

  • Titer
  • Structure
  • RNA content
  • Contaminant analysis

Exosomes

  • Size
  • Concentration
  • Phenotype

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Lunatic - Quantification

The next-gen protein and nucleic acid quantification system.

  • 2 µL volume
  • 96 samples
  • 10 minutes
  • SBS plate format

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Stunner - Quantification and sizing

The ultimate quantification and sizing tool.

LNPs

  • Sizing & polydispersity
  • Particle concentration
  • Aggregation
  • Total RNA quant

Biologics

  • Protein quant
  • Sizing & polydispersity
  • Molecular weight
  • Aggregation detection
  • B22 & kD
  • Conjugate characterisation

Viral Vectors

  • Capsid titre
  • Empty/full ratio
  • Aggregation
  • Sizing & polydispersity

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Uncle - Stability

The first all-in-one biologics stability screening platform.

  • Tm & T agg
  • Isothermal stability
  • Viral capsid stability
  • Tm with SYPRO (DSF)
  • Sizing & polydispersity
  • Sizing with thermal ramp
  • Thermal recovery
  • Viscosity
  • kD
  • B22
  • G22
  • ΔG

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Unagi - Buffer exchange

The only completely hands-free benchtop buffer exchange solution.

  • Protein
  • mRNA & DNA
  • AAV
  • LNP

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Big Tuna - Plate-based buffer exchange

The ultimate automated buffer exchange solution.

  • AAV
  • LNP
  • VLP
  • mRNA & DNA
  • Protein

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Honeybun - Viscosity

The most rapid viscometer out there.

  • 10 at a time
  • 35 μL per sample
  • 1 minute runs (≤10 cP)
  • Up to 150 cP

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Junior - Configurable benchtop automation

The all-around configurable benchtop workflow solution.

  • Formulation screening and optimisation
  • Visual inspection
  • Sample preparation
  • Reaction screening
  • Powder dispensing
  • Pressurised reactors
  • Process chemistry

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Big Kahuna - Configurable end-to-end workflow solution

The most customisable automated workflow solution.

  • Formulation screening and optimisation
  • Visual inspection
  • Sample preparation
  • Reaction screening
  • Powder dispensing
  • Pressurised reactors
  • Process chemistry

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Sunscreen - Automated formulation screening

The primo LNP formulation screener.

  • 96 formulations in <6 hours
  • 200 μL – 2 mL per experiment
  • 0.1 – 30 mL/min flow rates
  • Reusable microfluidics
  • Scalable method

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Sunshine - Formulation optimisation and scale-up

The all-around LNP process developer.

  • 10 experiments in 15 minutes
  • Fractional & total flow rates
  • 1 mL to continuous flow
  • 0.1 — 30 mL/min flow rates
  • Reusable microfluidics
  • Protocol transfer from Sunscreen

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